Contents Leading article Effects of ACE inhibition on cardiovascular and microvascular outcomes in people with diabetes mellitus The findings of the HOPE study ( also available as 'Online PDF file' which can be read in Adobe Acrobat Reader, a no-cost program.) Clinical reviews ( also available as 'Online PDF file' which can be read in Adobe Acrobat Reader, a no-cost program.) Low fitness and sedentariness predict mortality in Type 2 diabetes Progression of kidney disease in normotensive Type 1  diabetic patients  Alcohol consumption and incidence of Type 2 diabetes Insulin aspart and long-term glycaemic control Weight loss with orlistat improves glucose tolerance Meeting the insulin needs of the world’s poorest countries  GLP-I does not change insulin action or glucose effectiveness in Type 2 diabetes  Pulsatile insulin secretion and repaglinide administration C-peptide treatment in nephropathy and neuropathy